Metadata

Name Chronic Kidney Disease
Type Disease or Syndrome
Group Genitourinary
Data Sources
Clinical Terminologies
Codelists
Valid Event Data Range 01/01/1999 - 01/07/2016
Sex Female
Male
Authors Kuan V, Denaxas S, Gonzalez-Izquierdo A, Direk K, Bhatti O, Husain S, Sutaria S, Hingorani M, Nitsch D, Parisinos C, Lumbers T, Mathur R, Sofat R, Casas JP, Wong I, Hemingway H, Hingorani A
Agreement Date 20 May 2019
Version (UUID) 1 (g6TjPwLiMqVwz7YtFMa8eQ)

Implementation

Apply modified CALIBER 'Chronic Kidney Disease' algorithm in CPRD primary care data as follows:

A patient is defined as having had CKD stage 3 or above at a specified date:

IF egfr_ckdepi recorded on or before specified date, THEN 
IF egfr_ckdepi <60 ml/min on the most recent date (index date) before the specified date
AND
IF egfr_ckdepi <60 ml/min on any date greater than 90 days BEFORE the index date above
THEN classify as having CKD3 or above
ELSE the patient is not defined as having CKD stage 3 or above.

Where egfr_ckdepi up to and including 31 Dec 2013 is defined as: 
egfr_ckdepi = 141 * min(crea_gprd * 0.010746 / K, 1)^alpha
* max(crea_gprd * 0.010746 / K, 1)^-1.209 
* 0.993^age * 1.018 [if female]  * 1.159 [if black]

where:
alpha = -0.329 for females, -0.411 for males
K = 0.7 for females, 0.9 for males

Where egfr_ckdepi from and including 1 Jan 2014 is defined as: 
egfr_ckdepi = 141 * min(crea_gprd * 0.010746 / K, 1)^alpha
* max(crea_gprd * 0.0.011312/ K, 1)^-1.209 
* 0.993^age * 1.018 [if female]  * 1.159 [if black]

where:
alpha = -0.329 for females, -0.411 for males
K = 0.7 for females, 0.9 for males

Where crea_gprd is defined as:
IF enttype = 165 [Serum creatinine] 
AND data1 [Operator] = 3 ["="] AND data2 [Value] > 0
THEN crea_gprd = data2

Publications

Kuan V., Denaxas S., Gonzalez-Izquierdo A. et al. A chronological map of 308 physical and mental health conditions from 4 million individuals in the National Health Service. The Lancet Digital Health - DOI 10.1016/S2589-7500(19)30012-3