Metadata

Name Immunodeficiencies
Type Disease or Syndrome
Group Haematological or immunological
Data Sources

Clinical Terminologies Read Version 2
ICD-10
Codelists kuan_immunodef_F6u5wxYWxj4F6gFtp34TPq_Read2.csv kuan_immunodef_F6u5wxYWxj4F6gFtp34TPq_ICD10.csv
Valid Event Data Range 01/01/1999 - 01/07/2016
Sex Female
Male
Authors Kuan V, Denaxas S, Gonzalez-Izquierdo A, Direk K, Bhatti O, Husain S, Sutaria S, Hingorani M, Nitsch D, Parisinos C, Lumbers T, Mathur R, Sofat R, Casas JP, Wong I, Hemingway H, Hingorani A
Agreement Date 20 May 2019
Version (UUID) 1 (F6u5wxYWxj4F6gFtp34TPq)

Primary care

Disease Readcode Medcode ReadcodeDescr Category
Immunodeficiencies C390000 15137.0 Hypogammaglobulinaemia NOS Diagnosis of Immunodeficiencies
Immunodeficiencies C390100 8548.0 Selective IgA immunodeficiency Diagnosis of Immunodeficiencies
Immunodeficiencies C390200 18701.0 Selective IgM immunodeficiency Diagnosis of Immunodeficiencies
Immunodeficiencies C390300 18700.0 Selective IgG immunodeficiency Diagnosis of Immunodeficiencies
Immunodeficiencies C390400 68440.0 Other selective immunoglobulin deficiency Diagnosis of Immunodeficiencies
Immunodeficiencies C390500 57161.0 Congenital hypogammaglobulinaemia Diagnosis of Immunodeficiencies
Immunodeficiencies C390511 65603.0 Bruton's agammaglobulinaemia Diagnosis of Immunodeficiencies
Immunodeficiencies C390512 60880.0 Congenital X-linked agammaglobulinaemia Diagnosis of Immunodeficiencies
Immunodeficiencies C390600 69373.0 Immunodeficiency with IgM hypergammaglobulinaemia Diagnosis of Immunodeficiencies
Immunodeficiencies C390700 57322.0 Common variable immunodeficiency Diagnosis of Immunodeficiencies
Immunodeficiencies C390800 92569.0 Transient infant hypogammaglobulinaemia Diagnosis of Immunodeficiencies
Immunodeficiencies C390900 62598.0 Agammaglobulinaemia NEC Diagnosis of Immunodeficiencies
Immunodeficiencies C390A00 69184.0 Dysimmunoglobulinaemia NEC Diagnosis of Immunodeficiencies
Immunodeficiencies C390A11 43653.0 Dysgammaglobulinaemia NEC Diagnosis of Immunodeficiencies
Immunodeficiencies C390B00 60026.0 Antibod def wth nr-norm imunoglob/or wth hyperimunoglobaemia Diagnosis of Immunodeficiencies
Immunodeficiencies C390.00 44147.0 Deficiencies of humoral immunity Diagnosis of Immunodeficiencies
Immunodeficiencies C390.11 35682.0 Agammaglobulinaemia Diagnosis of Immunodeficiencies
Immunodeficiencies C390y00 69854.0 Other specified deficiency of humoral immunity Diagnosis of Immunodeficiencies
Immunodeficiencies C390z00 16295.0 Deficiency of humoral immunity NOS Diagnosis of Immunodeficiencies
Immunodeficiencies C391000 50665.0 Predominantly T-cell immuno-deficiency NOS Diagnosis of Immunodeficiencies
Immunodeficiencies C391011 48035.0 T-lymphocyte deficiency Diagnosis of Immunodeficiencies
Immunodeficiencies C391012 60758.0 Cellular immunity syndrome Diagnosis of Immunodeficiencies
Immunodeficiencies C391100 10955.0 Di George syndrome Diagnosis of Immunodeficiencies
Immunodeficiencies C391200 31322.0 Wiskott - Aldrich syndrome Diagnosis of Immunodeficiencies
Immunodeficiencies C391211 42439.0 Thrombocytopenic eczema with immunodeficiency Diagnosis of Immunodeficiencies
Immunodeficiencies C391.00 48307.0 Deficiencies of cell-mediated immunity Diagnosis of Immunodeficiencies
Immunodeficiencies C392100 48293.0 Severe combined immunodeficiency Diagnosis of Immunodeficiencies
Immunodeficiencies C392111 94120.0 Swiss type agammaglobulinaemia Diagnosis of Immunodeficiencies
Immunodeficiencies C392300 31541.0 Severe combined immunodefiency with reticular dysgenesis Diagnosis of Immunodeficiencies
Immunodeficiencies C392400 66073.0 Severe combined immunodef with low T- and B-cell numbers Diagnosis of Immunodeficiencies
Immunodeficiencies C392500 49542.0 Severe combined immunodef with low or normal B-cell numbers Diagnosis of Immunodeficiencies
Immunodeficiencies C392600 72804.0 Adenosine deaminase deficiency Diagnosis of Immunodeficiencies
Immunodeficiencies C392700 93936.0 Purine nucleoside phosphorylase deficiency Diagnosis of Immunodeficiencies
Immunodeficiencies C392800 50526.0 Major histocompatibility complex class I deficiency Diagnosis of Immunodeficiencies
Immunodeficiencies C392900 103977.0 Major histocompatibility complex class II deficiency Diagnosis of Immunodeficiencies
Immunodeficiencies C392.00 62236.0 Combined immunity deficiency Diagnosis of Immunodeficiencies
Immunodeficiencies C392z00 62328.0 Combined immunity deficiency NOS Diagnosis of Immunodeficiencies
Immunodeficiencies C393.00 3129.0 Unspecified immunity deficiency Diagnosis of Immunodeficiencies
Immunodeficiencies C395.00 65617.0 Immunodeficiency with short-limbed stature Diagnosis of Immunodeficiencies
Immunodeficiencies C396.00 56108.0 Immunodef follow hereditary defect respon Epstein-Barr vir Diagnosis of Immunodeficiencies
Immunodeficiencies C397.00 54203.0 Hyperimmunoglobulin E syndrome Diagnosis of Immunodeficiencies
Immunodeficiencies C398000 93892.0 Com var immunodef with predom abn B-cell numbers and functns Diagnosis of Immunodeficiencies
Immunodeficiencies C398200 66857.0 Common variable immunodef wth autoantibod to B- or T-cells Diagnosis of Immunodeficiencies
Immunodeficiencies C398.00 21975.0 Common variable immunodeficiency Diagnosis of Immunodeficiencies
Immunodeficiencies C39X.00 39800.0 Immunodeficiency associated+major defect, unspecified Diagnosis of Immunodeficiencies
Immunodeficiencies C39y000 54904.0 Lymphocyte function antigen-1 defect Diagnosis of Immunodeficiencies
Immunodeficiencies Cyu0000 106788.0 [X]Other immunodeficiencies+predominantly antibody defects Diagnosis of Immunodeficiencies
Immunodeficiencies Cyu0400 73131.0 [X]Other common variable immunodeficiencies Diagnosis of Immunodeficiencies
Immunodeficiencies Cyu0500 66386.0 [X]Other specified immunodeficiency disorders Diagnosis of Immunodeficiencies

Secondary care

Diagnoses

Disease ICD10code ICD10codeDescr Category
Immunodeficiencies D80 Immunodeficiency with predominantly antibody defects Diagnosis of Immunodeficiencies
Immunodeficiencies D81 Combined immunodeficiencies Diagnosis of Immunodeficiencies
Immunodeficiencies D82 Immunodeficiency associated with other major defects Diagnosis of Immunodeficiencies
Immunodeficiencies D83 Common variable immunodeficiency Diagnosis of Immunodeficiencies
Immunodeficiencies D84.0 Lymphocyte function antigen-1 [LFA-1] defect Diagnosis of Immunodeficiencies
Immunodeficiencies D84.8 Other specified immunodeficiencies Diagnosis of Immunodeficiencies
Immunodeficiencies D84.9 Immunodeficiency, unspecified Diagnosis of Immunodeficiencies

Implementation

At the specified date, a patient is defined as having had 'Immunodeficiencies' IF they meet the criteria for any of the following on or before the specified date. The earliest date on which the individual meets any of the following criteria on or before the specified date is defined as the first event date:

Primary care
1. 'Immunodeficiencies' diagnosis or history of diagnosis during a consultation 
OR
Secondary care (ICD10)
1. ALL diagnoses of 'Immunodeficiencies' or history of diagnosis during a hospitalization

Publications

Kuan V., Denaxas S., Gonzalez-Izquierdo A. et al. A chronological map of 308 physical and mental health conditions from 4 million individuals in the National Health Service. The Lancet Digital Health - DOI 10.1016/S2589-7500(19)30012-3